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Disabling the Windows Defender antivirus, which helps keep Windows 10 secure, and other system components you may actually want, like OneDrive.

Breaking the Windows Store, preventing you from installing apps from there and preventing it from updating the included applications in Windows 10.

Tampering with the hosts file to block specific Microsoft web servers, leading to various problems like Skype failing to synchronize chat messages or being unable to update itself.

Blocking Windows Update completely, preventing the installation of important security updates and leaving your PC vulnerable.

Tools of this type can cause a variety of problems, and if you look around the web, you can see plenty of instances of people experiencing those problems.